Evaluating the effect of aquatic extraction of Cannabis sativa seed on spatial memory consolidation
نویسندگان
چکیده
Background The existence of an endocannabinoid system in the central nervous system that consists of G protein-coupled CB1 cannabinoid receptor and endocannabinoids, including arachidonylethanolamide and anandamideand 2-rachidonoylglycerol, has gained general acceptance. Recent reports suggest that this system may serve several physiological functions thus, this research has tried to examine the research is the role of Tetrahyrocannabinol on learning process and spatial memory consolidation.
منابع مشابه
Evaluating the effect of aquatic extraction of Cannabis sativa seed on spatial memory consolidation in rats
Materials and methods 40 male wistar rats (3-4 month, 320-260 g) were completely divided into 4 experimental groups and control group. Cannabis sativa seed was extracted with Soxhlet apparatus. To test spatial memory, Morris water mazemaze (7 days,4 trails) was used. Experimental groups with 50 mg.kg, 100 mg.kg, 150 mg.kg, 210 mg.kg were injected in the peritoneal (IP) orderly and after one hou...
متن کاملEvaluating the effect of Tetrahydrocannabinol (∆9-THC) extracted from Cannabis sativa plant on spatial memory consolidation in rats
Background As the point of physiology, memories form changes in the conducting message in the neural webs. These changes cause the formation of long-term potentiation. Δ9-THC is a psychotropic component of Cannabis sativa plant. Studies show this matter can bind Cannabinoid receptor in CA1 area of Hippocamp. Thus the aim of this study is to evaluate the effect of aqua extraction Cannabis sativa...
متن کاملEffect of 3 Alpha-Anderostanediol and Indomethacin on Acquisition, Consolidation and Retrieval Stage of Spatial Memory in Adult Male Rats
Background: Testosterone and its metabolites have important roles in learning and memory. The current study has conducted to assess the effect of pre-training, post-training and pre-probe trial intrahippocampal CA1 administration of 3 alpha-anderostanediol (one of the metabolites of testosterone) and indomethacin (as 3 alpha-hydroxysteroid dehydrogenase enzyme blocker) on acquisition, consolida...
متن کاملKisspeptin-13 Improves Spatial Memory Consolidation and Retrieval against Amyloid-β Pathology
It has been shown that brain glucose metabolism impairment, obesity, and diabetes couldlead to cognitive decline and Alzheimer’s disease (AD) pathogenesis. Kisspeptin (KP) a G-proteincoupled receptor neuropeptide, has been suggested as a link between energy balance andreproduction. Some studies have shown that the attenuation of KP signaling decreases metabolismand energ...
متن کاملKisspeptin-13 Improves Spatial Memory Consolidation and Retrieval against Amyloid-β Pathology
It has been shown that brain glucose metabolism impairment, obesity, and diabetes couldlead to cognitive decline and Alzheimer’s disease (AD) pathogenesis. Kisspeptin (KP) a G-proteincoupled receptor neuropeptide, has been suggested as a link between energy balance andreproduction. Some studies have shown that the attenuation of KP signaling decreases metabolismand energ...
متن کامل